Selected References

History & Basics of SMBC

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Abel, S., Juza, M.	Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry	Chiral Separation Techniques: A Practical Approach	Wiley-VCH Verlag	2007	203-273
Broughton, D.B.	Molex: Case history of a process	Chem. Eng. Prog.	64	1968	60-65
Broughton, D.B., Gerhold, C.G.	Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets	US Patent 2 985 589		1961
Blehaut, J., Nicoud, R.-M.	Recent aspects in simulated moving bed	Novasep Analusis Magazine	26	1998	M60-M70
Ching, C.B., Ruthven, D.M., Hidajat, K.	Experimental study of a simulated counter-current adsorption system. III: Sorbex operation	Chem. Eng. Sci.	40	1985	1411-1417
Gomez, P.S., Rodrigues, A.E.	Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept	Chem. Eng. Technol.	34	2011	1-19
Imamoglu, S.	Simulated moving bed chromatography (SMB) for application in bioseparation	Advances in Biochemical Engineering/ Biotechnology	76	2002	211-231
Ma, Z., Wang, N.H.L.	Standing wave analysis of SMB chromatography: linear systems	AIChE J.	43	1997	2488-2508
Strube, J., Haumreisser, S., Schmidt-Traub, H., Schulte, M., Ditz, R.	Comparison of Batch Elution and Simulated Moving Bed Chromatography	Organic Process Research & Development	2	1998	305-319

SMBC Method Development

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Abel, S., Mazzotti, M., Morbidelli, M.	Solvent gradient operation of simulated moving beds: Linear isotherms	J. Chromatogr. A.	944	2002	23-39
deRosset, A.J., Neuzil, R.W., Korous, D.J.	Liquid Column Chromatography as a Predictive Tool for Continuous Countercurrent Adsorptive Separations	Ind. Eng.Chem., Process Des. Dev.	15	1976	261-266
Dunnebier, G., Klatt, K.-U.	Modeling and simulation of nonlinear chromatographic separation processes: a comparison of different modeling approaches	Chem. Eng. Sci.	55	2000	373-380
Feist, S.D., Hasabnis, Y., Pynnonen, B.W., Frank, T.C.	SMB Chromatography Design Using Profile Advancement Factors, Miniplant Data, and Rate-Based Process Simulations	AIChE J.	55	2009	2848-2860
Houwing, J., Jensen, T.B., van Hateren, S.H., Billiet, H.A.H., van der Wielen, L.A.M.	Positioning of salt gradients in ion-exchange SMB	AIChE J.	49	2004	665-674
Jacobson, J., Frenz, J., Horvath, C.	Measurement of Adsorption Isotherm by Liquid Chromatography	J. Chromatogr.	316	1984	53-68
Juza, M.	Development of a high-performance liquid chromatographic simulated moving bed separation from an industrial perspective	J. Chromatogr. A	865	1999	35-49
Lisec, O., Hugo, P., Seidel-Morgenstern, A.	Frontal Analysis Method to Determine Competitive Adsorption Isotherms	J. Chromatogr. A	908	2001	19-34
Seidel-Morgenstern, A	Experimental Determination of Single Solute and Competitive Adsorption Isotherms	J. Chromatogr. A	1037	2004	255-272
Storti, G., Masi, M., Carra, S., Morbidelli, M.	Optimal design of multicomponent countercurrent adsorption separation processes involving nonlinear equilibria	Chem. Eng. Sci.	44	1989	1329-1345
Toumi, A., Engell, S., Diehl. M., Bock, H.G., Schloder, J.	Efficient Optimization of Simulated Moving Bed Processes	Chem. Eng. & Proc.	46	2007	1067-1084
Zhong, G., Guiochon, G.	Analytical solution for the linear ideal model of simulated moving bed chromatography	Chem. Eng. Sci.	51	1996	4307

SMBC for Chiral Separation

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Kaiser, P., Ottolina. G., Carrea, G., Wohlgemuth, R.	Preparative-scale Separation   by Simulated Moving Bed Chromatography of Biocatalytically Produced Regioisomeric Lactones	New Biotechnology	25	2009	220-225
Kaspereit, M., Gedicke, K., Zahn. V., Mahoney, A.W., Seidel-Morgenstern, A	Shortcut method for evaluation and design of a hybrid process for enantioseparations	J. Chromatogr. A	1092	2005	43-54
Migliorini, C., Mazzotti, M., Zenoni, G., Morbidelli, M.	Shortcut experimental method for designing chiral SMB separations	AIChE J.	48	2002	69-77
Miller, L., Orihuela, C., Fronek, R., Honda, D., Dapremont, O.	Chromatographic resolution of the enantiomers of a pharmaceutical intermediate from the milligram to the kilogram scale.	J. Chromatogr. A	849	1999	309-317
Pedeferri, M.P., Zenoni, G., Mazzotti, M., Morbidelli, M.	Experimental analysis of a chiral separation through simulated moving bed chromatography	Chem. Eng. Sci.	54	1999	3735-3748
Perrin, S.R. and Nicoud, R.M.	The Use of SMB for the Manufacture of Enantiopure Drug Substances	Principle to cGMP Compliance: in Chiral Separation Techniques: A Practical Approach	Second Edition (ed. by G. Subramanian) Wiley-VCH Verlag	2001	253-285
Schulte, M., Strube, J.	Preparative Enantioseparation by Simulated Moving Bed Chromatography	J. Chromatogr. A	906	2001	399-416
Yan, T.Q., Orihuela, C., and Swanson, D.	The Application of Preparative Batch HPLC, Supercritical Fluid Chromatography, Steady-State Recycling, and Simulated Moving Bed for the Resolution of a Racemic Pharmaceutical Intermediate	Chirality	20	2008	139-146

SMBC for Protein Purification

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Andersson, J., Mattiasson, B.	Simulated moving bed technology with a simplified approach for protein purification: Separation of lactoperoxidase and lactoferrin from whey protein concentrate	J. Chromatogr. A	1107	2006	88-95
Andersson, J., Sahoo, D., Mattiasson, B.	Isolation of Potato Proteins Using Simulated Moving Bed Technology	Biotechnology and Bioengineering	101	2008	1256-1263
Freydell, E.J., Bulsink, Y., van Hateren, S., van der Wielen, L., Eppink, M., Ottens, M.	Size-Exclusion Simulated Moving Bed Chromatographic Protein Refolding	Chem. Eng. Sci.	65	2010	4701-4713
Gottschlich, N., Weidgen, S., Kasche, V.	Continuous biospecific affinity purification of enzymes by simulated moving bed chromatography: Theoretical description and experimental results	J .Chromatogr. A	719	1996	267-274
Gottschlich, N., Kasche, V.	Purification of monoclonal antibodies by simulated moving bed chromatography	J .Chromatogr. A	765	1997	201-206
Gueorguieva, L., Palani, S. Rinas, U.,Jayaraman, G., Seidel-Morgenstern, A.	Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: process design and experimental validation	J. Chromatogr. A	1218	2011	6402-6411
Gueorguieva, L., Vallejo, L.F., Rinas, U., Seidel-Morgenstern, A.	Discontinuous and continuous separation of the monomeric and dimeric forms of human bone morphogenetic protein-2 from renaturation batches	J. Chromatogr. A	1135	2006	142-150
Houwing, J., Billiet, H.A.H., van der Wielen, L.A.M.	Mass transfer effects during separation of proteins in SMB by size exclusion.	AICHE J.	49	2003	1158-1167
Houwing, J., Jensen, T.B., van Hateren, S.H., Billiet, H.A.H., van der Wielen, L.A.M.	Effect of salt gradients on the separation of dilute mixtures of proteins by ion exchange in SMB	J. Chromatogr. A	952	2002	85-98
Huang, S.Y., Ulbrecht, J.J., Lin, C.K., Chang, W.H., Lee, W.S.	Enzyme purification and concentration by simulated moving bed chromatography: An experimental study	Chem. Eng. Com.	45	1986	291-309
Kessler, L.C., Gueorguieva, L., Rinas, U., Seidel-Morgenstern, A.	Step gradients in 3-zone simulated moving bed chromatography applications to the purification of antibodies and bone morphogenetic protein-2	J. Chromatogr. A	1176	2007	69-78
Li, P., Xiu, G., Rodrigues, A.E.	Protein separation and purification by salt gradient ion-exchange SMB	AIChE J.	53	2007	2419-2431
Palani, S., Gueorguieva, L., Rinas, U.,Seidel-Morgenstern, A., Jayaraman, G.	Recombinant protein purification using gradient-assisted simulated moving bed hydrophobic interaction chromatography. Part I: Selection of chromatographic system and estimation of adsorption isotherms	J. Chromatogr. A		2011	6396-6401
Park, B.J., Lee, C.H., Koo, Y.M.	Development of novel protein refolding using simulated moving bed chromatography	Korean J. Chem. Eng.	22	2005	425-432
Sahoo, D., Andersson, J. and Mattiasson, B.	Immobilized metal affinity chromatography in open-loop simulated moving bed technology: Purification of heat stable, histidine tagged ß-glucosidase	Chromatogr. B	877:16-17	2009	1651-1656
Stroehlein, G., Aumann, L., Mueller-Spaeth, T., Tarafder, A., Morbidelli, M.	Continuous processing: The multicolumn countercurrent solvent gradient purification process	BioPharm International		2007	1-6
Xie, Y., Mun, S., Kim, J., Wang, N.H.L.	Standing Wave Design and Experimental Validation of a Tandem Simulated Moving Bed Process for Insulin Purification	Biotechnol. Prog.	18	2002	1332-1344

SMBC for Sugar, Sugar Alcohol, and Oligosaccharide Separation

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Azevedo, D.C.S., Rodrigues, A.E.	Separation of Fructose and Glucose from Cashew Apple Juice by SMB Chromatography	Separation Sciences and Technology	40	2005	1761-1780
Giesser, A., Hendrich, T., Boehm, G., Stahl, B.	Separation of Lactose from Human Milk Oligosaccharides with Simulated Moving Bed Chromatography	J. Chromatogr. A	1092	2005	17-23
Lee, K.N.	Continuous Separation of Glucose and Fructose at High Concentration Using Two-Section Simulated Moving Bed Process	Korean J. Chem. Eng.	20	2003	532-537
Lee, J. W., Kim, J., Lee, C.H., Kim, J.K., Koo, Y.	Design and Sensitivity Analysis of Simulated Moving Bed Chromatography to Separate Sugar Alcohols	Journal of Liquid Chromatography & Related Technologies	30	2007	1859-1877
Springfield, R.M., Hester, R.D.	Continuous Ion-Exclusion Chromatography System for Acid/Sugar Separation	Separation Sciences and Technology	34	1999	1217-1241

SMBC for Amino Acid Separation

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Molnar, Z., Nagy. M., Aranyi, A., Hanak, L., Argyelan, J., Pencz. I., Szanya, T.	Separation of Amino Acids with   Simulated Moving Bed Chromatography	J. Chromatogr. A	1079	2005	77-86

SMBC for Small Molecule Separation from Fermentation Broth

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Boogers, I.A.L.A., Van De Sandt, E.J.A.X., Schipper, D.	Process for the Fermentative Production of Cephalosporin	US Patent 6 552 185		2003
Hilaly, A.P., Binder, T.P.	Method of Recovering 1,3-Propandiol from Fermentation Broth	US Patent 6 479 716		2002
Kulprathipanja. S., Oroskar, A.R.	Separation of Lactic Acid from Fermentation Broth With an Anionic Polymeric Absorbent	US Patent 5 068 418		1991
Soper, J., Hilaly, A.K., Moore, K., Binder, T.P.	Method for Separating a Basic Amino Acid from Fermentation Broth	US Patent 6 479 700		2002

SMBC for Fatty Acid and Phospholipid Separation

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Lu. Y., Yang, Y., Wu, P.	Separation of Phosphatidylcholine from Soybean Phospholipids by Simulated Moving Bed	J. Zhejiang Univ SCIENCE B	7	2006	559-564
Perrut, M., Nicoud, R.-M., Breivik, H.	Processes for Chromatographic Fractionations of Fatty Acids and Their Derivatives	US Patent 5 719 302		1998

SMBC for Nucleoside Purification

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Abel, S., Babler M.U., Arpagaus, C., Mazzotti, M., Stadler, J.	Two-fraction and Three-fraction Continuous Simulated Moving Bed Separation of Nucleosides	J. Chromatogr. A	1043	2004	201-210
Kim, I.H.	Separation Simulation of Cytosine and Guanine by 3-Zone Simulated Bed (SMB)	Theories and Applications of Chem. Eng.	16	2010	1472

SMBC for Bio-active Compound Purification from Plant Extracts

Authors	Title	Publication	Volume/ Publisher	Year	Pages
Cong, J., Lin, B.	Separation of Liquiritin by Simulated Moving Bed Chromatography	J. Chromatogr. A	1145	2007	190-194
Cremasco, M.A., Hritzko, B.J., Wang, N.H.L.	Experimental Purification of Paclitaxel from a Complex Mixture of Taxanes Using a Simulated Moving Bed	Braz. J. Chem. Eng.	26	2009	207-218