Selected References

History & Basics of SMBC
Authors Title Publication Volume/
Publisher		 Year Pages
Abel, S., Juza, M. Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry Chiral Separation Techniques: A Practical Approach Wiley-VCH Verlag 2007 203-273
Broughton, D.B. Molex: Case history of a process Chem. Eng. Prog. 64 1968 60-65
Broughton, D.B., Gerhold, C.G. Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets US Patent 2 985 589 1961
Blehaut, J., Nicoud, R.-M. Recent aspects in simulated moving bed Novasep Analusis Magazine 26 1998 M60-M70
Ching, C.B., Ruthven, D.M., Hidajat, K. Experimental study of a simulated counter-current adsorption system. III: Sorbex operation Chem. Eng. Sci. 40 1985 1411-1417
Gomez, P.S., Rodrigues, A.E. Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept Chem. Eng. Technol. 34 2011 1-19
Imamoglu, S. Simulated moving bed chromatography (SMB) for application in bioseparation Advances in Biochemical Engineering/
Biotechnology		 76 2002 211-231
Ma, Z., Wang, N.H.L. Standing wave analysis of SMB chromatography: linear systems AIChE J. 43 1997 2488-2508
Strube, J., Haumreisser, S., Schmidt-Traub, H., Schulte, M., Ditz, R. Comparison of Batch Elution and Simulated Moving Bed Chromatography Organic Process Research & Development 2 1998 305-319
Authors Title Publication Volume/
Publisher		 Year Pages
Abel, S., Mazzotti, M., Morbidelli, M. Solvent gradient operation of simulated moving beds: Linear isotherms J. Chromatogr. A. 944 2002 23-39
deRosset, A.J., Neuzil, R.W., Korous, D.J. Liquid Column Chromatography as a Predictive Tool for Continuous Countercurrent Adsorptive Separations Ind. Eng.Chem., Process Des. Dev. 15 1976 261-266
Dunnebier, G., Klatt, K.-U. Modeling and simulation of nonlinear chromatographic separation processes: a comparison of different modeling approaches   Chem. Eng. Sci. 55 2000 373-380
Feist, S.D., Hasabnis, Y., Pynnonen, B.W., Frank, T.C. SMB Chromatography Design Using Profile Advancement Factors, Miniplant Data, and Rate-Based Process Simulations AIChE J. 55 2009 2848-2860
Houwing, J., Jensen, T.B., van Hateren, S.H., Billiet, H.A.H., van der Wielen, L.A.M. Positioning of salt gradients in ion-exchange SMB AIChE J. 49 2004 665-674
Jacobson, J., Frenz, J., Horvath, C. Measurement of Adsorption Isotherm by Liquid Chromatography J. Chromatogr. 316 1984 53-68
Juza, M. Development of a high-performance liquid chromatographic simulated moving bed separation from an industrial perspective J. Chromatogr. A 865 1999 35-49
Lisec, O., Hugo, P., Seidel-Morgenstern, A. Frontal Analysis Method to Determine Competitive Adsorption Isotherms J. Chromatogr. A 908 2001 19-34
Seidel-Morgenstern, A Experimental Determination of Single Solute and Competitive Adsorption Isotherms J. Chromatogr. A 1037 2004 255-272
Storti, G., Masi, M., Carra, S., Morbidelli, M. Optimal design of multicomponent countercurrent adsorption separation processes involving nonlinear equilibria Chem. Eng. Sci. 44 1989 1329-1345
Toumi, A., Engell, S., Diehl. M., Bock, H.G., Schloder, J. Efficient Optimization of Simulated Moving Bed Processes Chem. Eng. & Proc. 46 2007 1067-1084
Zhong, G., Guiochon, G. Analytical solution for the linear ideal model of simulated moving bed chromatography Chem. Eng. Sci. 51 1996 4307
Authors Title Publication Volume/
Publisher		 Year Pages
Kaiser, P., Ottolina. G., Carrea, G., Wohlgemuth, R. Preparative-scale Separation   by Simulated Moving Bed Chromatography of Biocatalytically Produced Regioisomeric Lactones New Biotechnology 25 2009 220-225
Kaspereit, M., Gedicke, K., Zahn. V., Mahoney, A.W., Seidel-Morgenstern, A Shortcut method for evaluation and design of a hybrid process for enantioseparations J. Chromatogr. A 1092 2005 43-54
Migliorini, C., Mazzotti, M., Zenoni, G., Morbidelli, M. Shortcut experimental method for designing chiral SMB separations AIChE J. 48 2002 69-77
Miller, L., Orihuela, C., Fronek, R., Honda, D., Dapremont, O. Chromatographic resolution of the enantiomers of a pharmaceutical intermediate from the milligram to the kilogram scale. J. Chromatogr. A 849 1999 309-317
Pedeferri, M.P., Zenoni, G., Mazzotti, M., Morbidelli, M. Experimental analysis of a chiral separation through simulated moving bed chromatography Chem. Eng. Sci. 54 1999 3735-3748
Perrin, S.R. and Nicoud, R.M. The Use of SMB for the Manufacture of Enantiopure Drug Substances Principle to cGMP Compliance: in Chiral Separation Techniques: A Practical Approach Second Edition (ed. by G. Subramanian)
Wiley-VCH Verlag		 2001 253-285
Schulte, M., Strube, J. Preparative Enantioseparation by Simulated Moving Bed Chromatography J. Chromatogr. A 906 2001 399-416
Yan, T.Q., Orihuela, C., and Swanson, D. The Application of Preparative Batch HPLC, Supercritical Fluid Chromatography, Steady-State Recycling, and Simulated Moving Bed for the Resolution of a Racemic Pharmaceutical Intermediate Chirality 20 2008 139-146
Authors Title Publication Volume/
Publisher		 Year Pages
Andersson, J., Mattiasson, B. Simulated moving bed technology with a simplified approach for protein purification: Separation of lactoperoxidase and lactoferrin from whey protein concentrate J. Chromatogr. A 1107 2006 88-95
Andersson, J., Sahoo, D., Mattiasson, B. Isolation of Potato Proteins Using Simulated Moving Bed Technology Biotechnology and Bioengineering 101 2008 1256-1263
Freydell, E.J., Bulsink, Y., van Hateren, S., van der Wielen, L., Eppink, M., Ottens, M. Size-Exclusion Simulated Moving Bed Chromatographic Protein Refolding Chem. Eng. Sci. 65 2010 4701-4713
Gottschlich, N., Weidgen, S., Kasche, V. Continuous biospecific affinity purification of enzymes by simulated moving bed chromatography: Theoretical description and experimental results J .Chromatogr. A 719 1996 267-274
Gottschlich, N., Kasche, V. Purification of monoclonal antibodies by simulated moving bed chromatography J .Chromatogr. A 765 1997 201-206
Gueorguieva, L., Palani, S. Rinas, U.,Jayaraman, G., Seidel-Morgenstern, A. Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: process design and experimental validation J. Chromatogr. A 1218 2011 6402-6411
Gueorguieva, L., Vallejo, L.F., Rinas, U., Seidel-Morgenstern, A. Discontinuous and continuous separation of the monomeric and dimeric forms of human bone morphogenetic protein-2 from renaturation batches J. Chromatogr. A 1135 2006 142-150
Houwing, J., Billiet, H.A.H., van der Wielen, L.A.M. Mass transfer effects during separation of proteins in SMB by size exclusion. AICHE J. 49 2003 1158-1167
Houwing, J., Jensen, T.B., van Hateren, S.H., Billiet, H.A.H., van der Wielen, L.A.M. Effect of salt gradients on the separation of dilute mixtures of proteins by ion exchange in SMB J. Chromatogr. A 952 2002 85-98
Huang, S.Y., Ulbrecht, J.J., Lin, C.K., Chang, W.H., Lee, W.S. Enzyme purification and concentration by simulated moving bed chromatography: An experimental study Chem. Eng. Com. 45 1986 291-309
Kessler, L.C., Gueorguieva, L., Rinas, U., Seidel-Morgenstern, A. Step gradients in 3-zone simulated moving bed chromatography applications to the purification of antibodies and bone morphogenetic protein-2 J. Chromatogr. A 1176 2007 69-78
Li, P., Xiu, G., Rodrigues, A.E. Protein separation and purification by salt gradient ion-exchange SMB AIChE J. 53 2007 2419-2431
Palani, S., Gueorguieva, L., Rinas, U.,Seidel-Morgenstern, A., Jayaraman, G. Recombinant protein purification using gradient-assisted simulated moving bed hydrophobic interaction chromatography. Part I: Selection of chromatographic system and estimation of adsorption isotherms J. Chromatogr. A 2011 6396-6401
Park, B.J., Lee, C.H., Koo, Y.M. Development of novel protein refolding using simulated moving bed chromatography Korean J. Chem. Eng. 22 2005 425-432
Sahoo, D., Andersson, J. and Mattiasson, B. Immobilized metal affinity chromatography in open-loop simulated moving bed technology: Purification of heat stable, histidine tagged ß-glucosidase
  1. Chromatogr. B
 877:16-17 2009 1651-1656
Stroehlein, G., Aumann, L., Mueller-Spaeth, T., Tarafder, A., Morbidelli, M. Continuous processing: The multicolumn countercurrent solvent gradient purification process BioPharm International 2007 1-6
Xie, Y., Mun, S., Kim, J., Wang, N.H.L. Standing Wave Design and Experimental Validation of a Tandem Simulated Moving Bed Process for Insulin Purification Biotechnol. Prog. 18 2002 1332-1344
Authors Title Publication Volume/
Publisher		 Year Pages
Azevedo, D.C.S., Rodrigues, A.E. Separation of Fructose and Glucose from Cashew Apple Juice by SMB Chromatography Separation Sciences and Technology 40 2005 1761-1780
Giesser, A., Hendrich, T., Boehm, G., Stahl, B. Separation of Lactose from Human Milk Oligosaccharides with Simulated Moving Bed Chromatography J. Chromatogr. A 1092 2005 17-23
Lee, K.N. Continuous Separation of Glucose and Fructose at High Concentration Using Two-Section Simulated Moving Bed Process Korean J. Chem. Eng. 20 2003 532-537
Lee, J. W., Kim, J., Lee, C.H., Kim, J.K., Koo, Y. Design and Sensitivity Analysis of Simulated Moving Bed Chromatography to Separate Sugar Alcohols Journal of Liquid Chromatography & Related Technologies 30 2007 1859-1877
Springfield, R.M., Hester, R.D. Continuous Ion-Exclusion Chromatography System for Acid/Sugar Separation Separation Sciences and Technology 34 1999 1217-1241
Authors Title Publication Volume/
Publisher		 Year Pages
Molnar, Z., Nagy. M., Aranyi, A., Hanak, L., Argyelan, J., Pencz. I., Szanya, T. Separation of Amino Acids with   Simulated Moving Bed Chromatography J. Chromatogr. A 1079 2005 77-86
Authors Title Publication Volume/
Publisher		 Year Pages
Boogers, I.A.L.A., Van De Sandt, E.J.A.X., Schipper, D. Process for the Fermentative Production of Cephalosporin US Patent 6 552 185 2003
Hilaly, A.P., Binder, T.P. Method of Recovering 1,3-Propandiol from Fermentation Broth US Patent 6 479 716 2002
Kulprathipanja. S., Oroskar, A.R. Separation of Lactic Acid from Fermentation Broth With an Anionic Polymeric Absorbent US Patent 5 068 418 1991
Soper, J., Hilaly, A.K., Moore, K., Binder, T.P. Method for Separating a Basic Amino Acid from Fermentation Broth US Patent 6 479 700 2002
Authors Title Publication Volume/
Publisher		 Year Pages
Lu. Y., Yang, Y., Wu, P. Separation of Phosphatidylcholine from Soybean Phospholipids by Simulated Moving Bed J. Zhejiang Univ SCIENCE B 7 2006 559-564
Perrut, M., Nicoud, R.-M., Breivik, H. Processes for Chromatographic Fractionations of Fatty Acids and Their Derivatives US Patent 5 719 302 1998
Authors Title Publication Volume/
Publisher		 Year Pages
Abel, S., Babler M.U., Arpagaus, C., Mazzotti, M., Stadler, J. Two-fraction and Three-fraction Continuous Simulated Moving Bed Separation of Nucleosides J. Chromatogr. A 1043 2004 201-210
Kim, I.H. Separation Simulation of Cytosine and Guanine by 3-Zone Simulated Bed (SMB) Theories and Applications of Chem. Eng. 16 2010 1472
Authors Title Publication Volume/
Publisher		 Year Pages
Cong, J., Lin, B. Separation of Liquiritin by Simulated Moving Bed Chromatography J. Chromatogr. A 1145 2007 190-194
Cremasco, M.A., Hritzko, B.J., Wang, N.H.L. Experimental Purification of Paclitaxel from a Complex Mixture of Taxanes Using a Simulated Moving Bed Braz. J. Chem. Eng. 26 2009 207-218